Great tips on workflow with Ableton live by ill.gates, a great producer and software coach.
Check out this great tutorial on his method of 128 samples in the native Ableton Live sampler.
There's also a live set and a pack of samples available for free download.
He illustrates here some smart ways of achieving a great workflow to produce sounds, like the ones created by Amon Tobin and Eskmo (two of the major sound designers and musical geniuses of our time), on their new project called Eskamon, which is just a beautifully constructed "Sound Sculpture", as Tobin calls it.